Endocrine Abstracts

Ovarian cancer is one of the major cause of death among women worldwide with high incidence. Ovarian cancer can be categorized into epithelial, non-epithelial (germ cell and sex cord-stromal cell), and metastatic (usually develop from surrounding cancerous organs). Recently, several approaches have been studied to control ovarian cancer at the transcriptional or post-transcriptional levels using small non coding RNAs including microRNAs. We carried out a meta-analysis of previ...

Introduction: Congenital Hyperinsulinism (CHI) is a heterogeneous condition caused by dysregulation of insulin secretion. Paternally inherited mutations in ABCC8 or KCNJ11 are associated with loss of the maternal 11p15 allele in focal CHI (CHI-F). CHI-F can be curative after selective lesionectomy. However, histological heterogeneity within the CHI-F lesions has not been previously reported. We aimed to examine the diversity in focal lesions and correlate wit...

Introduction: The National Paediatric Diabetes Audit consistently highlights disparity in Type 1 diabetes outcomes with a higher mean HbA1c observed in the most deprived socioeconomic groups. During COVID concerns escalated as the impact of lockdowns on socioeconomic deprivation had potential to inflate pre-existing health divides. Our study aimed to assess care provided and impact of socioeconomic background on diabetes outcomes through COVID in a large terti...

Background: The National Paediatric Diabetes Audit consistently highlights disparity in Type 1 diabetes outcomes across different ethnic groups. During COVID concerns escalated as the impact of lockdowns on ethnic minority groups had potential to inflate pre-existing health divides. This study aims to consider if COVID-19 differentially impacted children with Type 1 diabetes in different ethnic groups (White, Black, Asian, Mixed, Other)....